When patients get radiation treated for head and neck cancer they often suffer from mouth pain and sores, called mucositis. The radiation targets cells that are rapidly dividing, like cancer cells. Unfortunately, mouth tissue cells also rapidly divide and can suffer damage from the radiation treatment. Early research showed that a Doxepin oral rinse helped reduce pain associated with radiation cancer therapy for the head and neck. Researchers wanted to offer further treatment proof for this treatment as well as a new oral rinse called Magic Mouthwash. Magic Mouthwash contains an antihistamine (Diphenhydramine), a numbing agent (Lidocaine) and antacids. Both were tested side by side along with a control group, who received a placebo. Both treatments significantly reduced pain associated with mucositis as compared to the control group. They were also well tolerated by the study participants. This study concluded that these two oral rinses offer symptom relief from the side effects of radiation therapy for head and neck cancer.